Citicoline Sodium (CAS No: 33818-15-4)
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Citicoline Sodium (INN), also known as cytidine diphosphate-choline (CDP-Choline) & cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline. Studies suggest that CDP-choline supplements increase dopamine receptor densities, and suggest that CDP choline supplementation helps prevent memory impairment resulting from poor environmental conditions. Preliminary research has found that citicoline supplements help improve focus and mental energy and may possibly be useful in the treatment of attention deficit disorder. Citicoline has also been shown to elevate ACTH independently from CRH levels and to amplify the release of other HPA axis hormones such as LH, FSH, GH and TSH in response to hypothalamic releasing factors. These effects on HPA hormone levels may be beneficial for some individuals but may have undesirable effects in those with medical conditions featuring ACTH or cortisol hypersecretion including, but not limited to, PCOS, type II diabetes and major depressive disorder.
1. It is mainly used for disturbance of consciousness caused by acute craniocerebral trauma and brain surgery, and hemiplegia caused by cerebral apoplexy.
2. Can also be used for tinnitus and sensorineural deafness
Citicoline Sodium can reduce the resistance of blood vessel of brain and accelerate substance metabolism of brain. It also can activate the mechanism of reticular formation of brain stem. It can be used in the therapy of acute craniocerebral trauma and disturbance of consciousness after brain operation.